刘志刚

　　 　　

刘志刚，博士，教授，博士研究生导师。入选国家级人才，德国“洪堡学者”，美国“康奈尔大学唐氏·康奈尔-中国学者”， “陕西省高校科协青年人才托举计划”，曾任美国康奈尔大学食品科学系客座教授。现任西北农林科技大学食品科学与工程学院食品营养系副主任，食品营养与预防医学教研室主任，兼任德国人类营养研究所访问研究员、 Frontiers in Aging Neuroscience 杂志副主编。研究方向：食品营养与人类健康。

联系方式：zhigangliu@nwsuaf.edu.cn

一、教育与工作经历

2020年1月－至今，西北农林科技大学食品科学与工程学院，教授

2020年8月－至今，德国人类营养研究所，访问研究员/洪堡学者

2020年7月－2021年1月，美国Cornell University，Department of Food Science，客座教授

2017年2月－2020年1月，西北农林科技大学食品科学与工程学院，副教授

2019年7月－2020年7月，美国Cornell University，Department of Food Science，客座副教授

2015年9月－2017年1月，西北农林科技大学食品科学与工程学院，讲师

2013年8月－2015年8月，美国University of Southern California，School of Pharmacy，联合培养博士

2010年9月－2015年6月，西北农林科技大学食品科学与工程学院，食品科学，博士

2006年9月－2010年6月，西北农林科技大学食品科学与工程学院，食品质量与安全，工学学士

二、教学内容

本科课程：《食品营养与卫生学》、《营养与代谢》、《食品学科前沿讨论课》

研究生课程：《高级食品化学》、《现代食品营养学》、《食品科学Seminar》

三、主要研究方向

1. 膳食模式与肠脑健康互作机制：围绕神经系统和肠道功能的互作整合，针对阿尔兹海默症等神经退行性病变、压力引起的焦虑抑郁、生命早期1000天神经系统发育等脑健康问题，探究高膳食纤维饮食、间歇性禁食、氨基酸限制饮食等特色膳食模式通过影响肠道微生态结构、调节糖脂代谢平衡，进而干预中枢神经系统功能的营养干预作用，揭示膳食成分与结构通过影响外周系统进而影响脑健康的“肠-脑”轴机制。

2. 食品营养功能组分发掘与功效评价：结合我国特色食材资源和全民营养健康现状，发掘果蔬、粮油等传统食品原料及西部特色农产品中具有调节肠道微生态、糖脂代谢稳态、改善脑健康问题等生理功能的食物功能成分，发掘有益肠脑健康的植物化合物、益生菌、益生元等。

四、科研项目

近年来主持包括中国“脑计划”重大项目，国家自然科学基金面上项目、青年项目、陕西省重点研发计划、中国博士后特别资助、企业横向课题等科研项目10余项，主要在研项目包括：

1. 国家自然科学面上项目，No. 81871118，主持，在研

2. 国家自然科学基金青年项目，No. 81803231，主持，在研

3. 科技创新2030-“脑科学与类脑研究”重大项目（青年科学家），SQ2021AAA010802，，主持，在研

五、主要著作、论文及科技奖励情况

近年来在《中国食品学报》、 Cell Metabolism 、 Nature Communications 、 Redox Biology 、 Brain, Behavior, and Immunity ,  Molecular Nutrition & Food Research 、 Journal of Agricultural and Food Chemistry 等医学、生物学、食品营养及综合领域国内外高水平杂志发表论文80余篇，总引次数达3000次，H-index 32, i10-index 65。申报国家发明专利4项，获陕西省科学技术进步奖二等奖、陕西省高等学校科学技术一等奖、2020年陕西省科技工作者创新创业大赛银奖等奖项。

学术专著

1. William Shang（向玉龙）, 刘志刚《糖尿病自救攻略》Amazon KDP, 2020.（共同主编）

2. Zhigang Liu*, Harsh Sancheti, Enrique Cadenas*, and Fei Yin* (2015) Chapter 2: Energy-redox axis in mitochondria. Mitochondria in Liver Disease (Han, D. and Kaplowitz, N., Eds), pp. 29-43. CRC Press, Boca Raton.

代表性论文（所有论文列表请查看https://orcid.org/0000-0002-6863-6561）：

1. Wentong Zhang, Jun Wang, Luanfeng Wang, Renjie Shi, Chuanqi Chu, Zhiling Shi, Pujie Liu, Yitong Li, Xuebo Liu, Zhigang Liu∗. Alternate-day fasting prevents non-alcoholic fatty liver disease and working memory impairment in diet-induced obese mice.  Journal of Nutritional Biochemistry 2022 Aug 29; 110: 109146; doi: 10.1016/j.jnutbio.2022.109146.

2. Yuyu Zhang#, Julia Jelleschitz#, Tilman Grune, Weixuan Chen, Yihang Zhao, Mengzhen Jia, Yajie Wang, Zhigang Liu*, Annika Hohn*. Methionine restriction-Association with redox homeostasis and implications on aging and diseases.  Redox Biology 2022; 57, 102464. (Review)

3. JiangJiang Tang, LanFang Huang, JiaLe Deng, YiMeng Wang, Cong Guo, XiaoNa Peng, Zhigang Liu*, Jin-Ming Gao*. Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model.  Redox Biology 2022; 50:102229.

4. Yihang Zhao, Mengzhen Jia, Weixuan Chen, Zhigang Liu*. The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function.  Free Radical Biology & Medicine  2022; 182:206-218. (Review)

5. Lei Wang, Weixuan Chen, Yujie Tian, Xiaorong Duan, Yi Yuan, Na Wang, Chao Xu, Xuebo Liu, Zhigang Liu*. Preventive Effects of Sesamol on Deep-Frying Oil-Induced Liver Metabolism Disorders by Altering Gut Microbiota and Protecting Gut Barrier Integrity.  Molecular Nutrition & Food Research  2022; e2101122.

6. Ying Lan, Qingyang Sun, Zhiyuan Ma, Jing Peng, Mengqi Zhang, Chi Wang, Xiaotian Zhang, Xianfang Yan, Lili Chang, Xinglin Hou, Ruixue Qiao, Aiziguli Mulati, Yuan Zhou, Qiang Zhang, Zhigang Liu*, Xuebo Liu*. Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis.  Food & function 2022; 13(5):2925-2937.

7. Qing Liu, Tianzhi Xie, Yujia Xi, Ling Li, Fengfeng Mo, Xuebo Liu, Zhigang Liu*, Jin-Ming Gao, Tian Yuan*. Affiliations expand Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut-Brain Axis.  Journal of Agricultural and Food Chemistry  2021; 69:12717-12729.

8. Bo Ren, Luanfeng Wang, Lin Shi, Xin Jin, Yan Liu, Rui Hai Liu, Fei Yin, Enrique Cadenas, Xiaoshuang Dai, Zhigang Liu*, Xuebo Liu*. Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21.  Redox Biology 2021; 41:101940.

9. Qing Liu, Yujia Xi, Qianxu Wang, Jinhui Liu, Peiran Li, Xue Meng, Kai Liu, Weixuan Chen, Xuebo Liu, Zhigang Liu*. Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis.  Brain, Behavior, and Immunity 2021; doi.org/10.1016/j.bbi.2021.04.005.

10. Xiaoning Liu, Xiang Li, Bing Xia, Xin Jin, Qianhui Zou, Zhenhua Zeng, Weiyang Zhao, Shikai Yan, Ling Li, Shufen Yuan, Shancen Zhao, Xiaoshuang Dai, Fei Yin, Enrique Cadenas, Rui Hai Liu, Beita Zhao, Min Hou*, Zhigang Liu*, Xuebo Liu*. High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis.  Cell Metabolism 2021; doi.org/10.1016/j.cmet.2021.02.002.

11. Zhigang Liu*^#, Xiaoshuang Dai^#, Hongbo Zhang, Renjie Shi, Yan Hui, Xin Jin, Wentong Zhang, Luanfeng Wang, Qianxu Wang, Danna Wang, Jia Wang, Xintong Tan, Bo Ren, Xiaoning Liu, Tong Zhao, Jiamin Wang, Junru Pan, Tian Yuan, Chuanqi Chu, Lei Lan, Fei Yin, Enrique Cadenas, Lin Shi*. Shancen Zhao*; Xuebo Liu*. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.  Nature Communications  2020; 11(1):855.

12. Zhigang Liu^#, Ling Li^#, Shaobo Ma, Jin Ye, Hongbo Zhang, Yitong Li, Ali Tahir Sair, Junru Pan, Xiaoning Liu, Xiang Li, Shikai Yan, Xuebo Liu*. High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved.  Journal of Agricultural and Food Chemistry 2020; 68(47):13697-13710.

13. Beita Zhao, Bing Xia, Xiaohan Li, Li Zhang, Xiaoning Liu, Renjie Shi, Rongwei Kou, Zhigang Liu*, Xuebo Liu*. Sesamol Supplementation Attenuates DSS-Induced Colitis via Mediating Gut Barrier Integrity, Inflammatory Responses, and Reshaping Gut Microbiome.  Journal of Agricultural and Food Chemistry 2020; 68(39):10697-10708.

14. Xin Zhang, Qianhui Zou, Beita Zhao, Jingwen Zhang, Weiyang Zhao, Yitong Li, Ruihai Liu, Xuebo Liu, Zhigang Liu*. Effects of alternate-day fasting, time-restricted feeding and intermittent energy restriction on DSS-induced colitis and behavioral disorders.  Redox Biology 2020; 32:101535.

15. Hongbo Zhang, Wentong Zhang, Duo Yun, Ling Li, Weiyang Zhao, Yitong Li, Xuebo Liu*, Zhigang Liu*. Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: Roles of FGF21 and bile acids.  Journal of Nutritional Biochemistry  2020; 83:108403.

16. Qianhui Zou, Xin Zhang, Xiaoshuang Liu, Yitong Li, Qiaoli Tan, Qin Dan, Tian Yuan, Xuebo Liu, Ruihai Liu, Zhigang Liu*. Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice.  Food & function 2020; 11(7):6666-6679.

17. Luanfeng Wang, Bo Ren, Qian Zhang, Chuanqi Chu, Zhenting Zhao, Jianbin Wu, Weiyang Zhao, Zhigang Liu*, Xuebo Liu*. Methionine Restriction Alleviates High-Fat Diet-induced Obesity: Involvement of Diurnal Metabolism of Lipids and Bile Acids.  Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 2020; 1866(11):165908.

18. Luanfeng Wang, Bo Ren, Yan Hui, Chuanqi Chu, Zhenting Zhao, Yuyu Zhang, Beita Zhao, Renjie Shi, Junli Ren, Xiaoshuang Dai, Zhigang Liu*, Xuebo Liu*. Methionine Restriction Regulates Cognitive Function in High‐fat Diet‐fed Mice: Roles of Diurnal Rhythms of SCFAs Producing‐ and Inflammation‐ related Microbes.  Molecular Nutrition & Food Research 2020; 64(17):2000190.

19. Jia Wang, TonghuiGeng, Qianhui Zou, Ningru Yang, Weiyang Zhao, Yitong Li, Xintong Tan, Tian Yuan, Xuebo Liu, and Zhigang Liu*. Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function.  Journal of Functional Foods 2020; 67:103857.

20. Bo Ren, Tian Yuan, Xinglin Zhang, Luanfeng Wang, Junru Pan, Yan Liu, Beita Zhao, Weiyang Zhao, Zhigang Liu*, Xuebo Liu*. Protective Effects of Sesamol on Systemic Inflammation and Cognitive Impairment in Aging Mice.  Journal of Agricultural and Food Chemistry  2020; 68(10):3099-3111.

21. AiziguliMulati, Shaobo Ma, Hongbo Zhang, Bo Ren, Beita Zhao, Luanfeng Wang, Xiaoning Liu, Tong Zhao, Svetlana Kamanova, Ali Tahir Sair, Zhigang Liu*, Xuebo Liu*. Sea-Buckthorn Flavonoids Alleviate High-Fat and High-Fructose Diet-Induced Cognitive Impairment by Inhibiting Insulin Resistance and Neuroinflammation.   Journal of Agricultural and Food Chemistry 2020; 68(21):5835-5846.

22. Shikai Yan, Renjie Shi, Ling Li, Shaobo Ma, Hongbo Zhang, Jin Ye, Jiamin Wang, Junru Pan, Qianxu Wang, Xiang Jin, Xuebo Liu, Zhigang Liu*. Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western-Diet-Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short-Chain Fatty Acids Production.  Molecular Nutrition & Food Research  2019; 63(23): e1900521.

23. Xintong Tan, Ling Li, Jia Wang, Beita Zhao, Junru Pan, Leran Wang, Xiao Liu, Xuebo Liu, Zhigang Liu*. Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes.  Journal of Agricultural and Food Chemistry 2019; 67(31):8510-8519.

24. Cover Article: Qianxu Wang, Mengzhen Jia, Yihang Zhao, Yan Hui, Junru Pan, Hongfei Yu, Shikai Yan, Xiaoshuang Dai, Xuebo Liu, Zhigang Liu*. Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure.  Journal of Agricultural and Food Chemistry 2019; 67(45):12441-12451.

25. Yihang Zhao, Qianxu Wang, Mengzhen Jia, Shangchen Fu, Junru Pan, Chuanqi Chu, Xiaoning Liu, Xuebo Liu, Zhigang Liu*. (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation.  Journal of Nutritional Biochemistry 2019; 64:61-71.

26. Tian Yuan, Chuanqi Chu, Rubing Shi, Tianlin Cui, Xinglin Zhang, Yihang Zhao, Xu Shi, Yan Hui, Junru Pan, Rui Qian, Xiaoshuang Dai, Zhigang Liu*, Liu, Xuebo*. ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut-Brain Axis.  Journal of Agricultural and Food Chemistry 2019; 67(22):6190-6201.

27. Guoyuan Qi, Yashi Mi, Rong Fan, Zhigang Liu*, Xuebo Liu*. Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways.  Journal of Agricultural and Food Chemistry  2019; 67(18):5122-5134.

28. Zhigang Liu#, Xiaoning Liu#, Shunyi Luo, Chuanqi Chu, Dandan Wu, Runhua Liu, Lei Wang, Jiamin Wang, Xuebo Liu*. Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits.  Journal of Functional Foods 2018; 42:237-247.

29. Beita Zhao, Hua Liu, Jiamin Wang, Pujie Liu, Xintong Tan, Bo Ren, Zhigang Liu*, Xuebo Liu*. Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice.  Journal of Agricultural and Food Chemistry  2018; 66(12):3127-3136.

30. Rui Guo, Beita Zhao, Yijie Wang, Dandan Wu, Yutang Wang, Yafan Yu, Yuchen Yan, Wentong Zhang, Zhigang Liu*, Xuebo Liu*. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells.  Journal of Agricultural and Food Chemistry  2018; 66(37):9667-9678.

31. Jia Wang, Zhuo Wang, Bing Li, Yu Qiang, Tian Yuan, Xintong Tan, Zihan Wang, Zhigang Liu*, Xuebo Liu*. Lycopene attenuates western-diet induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis.   International Journal of Obesity 2018; 43(9):1735-1746.

32. Jia Wang, Lixia Li, Zhuo Wang, Yifan Cui, Xintong Tan, Tian Yuan, Qian Liu, Zhigang Liu*, Xuebo Liu*. Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress.  Journal of Nutritional Biochemistry  2018; 56:16-25.

33. Front Cover Article: Zhigang Liu^#, Yuwei Chen^#, Qinglian Qiao, Yali Sun, Qian Liu, Bo Ren, Xuebo Liu*. Sesamol supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB.  Molecular Nutrition & Food Research 2017; 61(5):1600734.

34. Zhigang Liu^#, QinglianQiao^#, Yali Sun, Yuwei Chen, Bo Ren, Xuebo Liu*. Sesamol ameliorates diet‐induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3‐L1 cells via regulating mitochondria‐lipid metabolism.  Molecular Nutrition & Food Research  2017; 61(8):1600717.

35. Zhigang Liu^#, Yali Sun^#, Qinglian Qiao, Tong Zhao, Wentong Zhang, Bo Ren, Qian Liu, Xuebo Liu*. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system.  Food & function  2017;8(2):710-719.

36. Zhigang Liu, Patil Ishan, Sancheti Harsh, Yin Fei, Cadenas Enrique*. Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and ¹³C-NMR Study.  Scientific Reports 2017; 7(1):5391.

37. Qian Liu, Yaya Hu, Youfang Cao, Ge Song, Zhigang Liu*, Xuebo Liu*. Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain.  Journal of Agricultural and Food Chemistry  2017; 65(2):338-347.

38. Zhigang Liu, Bo Ren, Yihui Wang, Chen Zou, Qinglian Qiao, Zhijun Diao, Yashi Mi, Di Zhu, Xuebo Liu*. Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy.  Scientific Reports 2017; 7:45728.

39. Ge Song#, Zhigang Liu#, Luanfeng Wang, Renjie Shi, Chuanqi Chu, Man Xiang, Qi Tian, Xuebo Liu*. Protective effects of lipoic acid against acrylamide-induced neurotoxicity: involvement of mitochondrial energy metabolism and autophagy.   Food & function 2017; 8:4657-4667.

40. Guoyuan Qi#, Zhigang Liu #, Rong Fan, Ziru Yin, Yashi Mi, Bo Ren, Xuebo Liu*. Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells.  Scientific Reports 2017; 7(1):2275.

41. Qian Liu, Yuwei Chen, Chun Shen, Yating Xiao, Yutang Wang, Zhigang Liu*, Xuebo Liu*. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis  via inhibition of NF-κB.  FASEB Journal 2017; 31(4):1494-1507.

42. Beita Zhao, Bo Ren, Rui Guo, Wentong Zhang, Shaobo Ma, Yuchen Yao, Tian Yuan, Zhigang Liu, Xuebo Liu*. Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway.  Food and chemical toxicology 2017; 109:505-516.

43. Zhigang Liu, Ge Song, Chen Zou, Gongguan Liu, Wanqiang Wu, Tian Yuan, Xuebo Liu*. Acrylamide induces mitochondrial dysfunction and apoptosis in BV-2 microglial cells.  Free Radical Biology & Medicine 2015; 84:42-53.

44. Zhigang Liu, Ishan Y Patil, Tianyi Jiang, Harsh Sancheti, John P Walsh, Bangyan L Stiles, Fei Yin, Enrique Cadenas. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity.  PLoS One . 2015; 10(5):e0128274.

45. Zhigang Liu, Qisen Xiang, Lihui Du, Ge Song, Yutang Wang, Xuebo Liu. The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells.  Food Chemistry 2013; 141(1):289-296.

46.  刘学波; 刘小宁; 原田; 刘志刚*  芝麻酚的神经保护作用及分子机制《中国食品学报》2017;17(10):1-7.

47. 刘学波*，张文彤，郭瑞，刘志刚 高脂高果糖膳食影响脑认知功能的分子机制与研究进展《中国食品学报》 2016;16(10):1-9. EI

48. 刘学波，刘志刚 线粒体介导食品功能因子活性与食品危害物毒性的分子机制《中国食品学报》2015;15(10):1-8. EI

代表性专利

1. 一种具有改善和缓解压力作用的芝麻木酚素咀嚼片；已授权；专利授权国：中国；专利号：2017102429392

2. 一种抗疲劳的苣荬菜运动饮料；已授权；专利授权国：中国；专利号：201710219898.5