刘志刚

　　 　　

刘志刚，博士，教授，博士研究生导师，陕西省精准营养与健康研究院院长。入选教育部 “青年长江学者”（食品营养与健康岗位，2021.4-2024.4），德国“洪堡学者”，美国康奈尔大学“唐-中国学者”。担任中国食品科学技术学会第四届青年委员会委员，陕西省营养学会常务理事，中国营养学会药食同源产业分会，中国食品学会特殊食品分会理事，中国生物物理学会肠道菌群分会理事，欧洲自由基研究学会会员（SFRR-Europe）， Food and Humanity Section  主编、 Frontiers in Aging Neuroscience ,  Frontiers in Aging Psychiatry ,  Frontiers in Neuroinflammation and Neuropathy Editor 副主编、 iMeta 青年编委、《中国食品学报》青年编委。研究方向：食品营养与人类健康。

联系方式：zhigangliu@nwsuaf.edu.cn

一、教育与工作经历

2020年1月－至今，西北农林科技大学食品科学与工程学院，教授

2020年8月－至今，德国人类营养研究所，访问研究员/洪堡学者

2020年7月－2021年1月，美国Cornell University，Department of Food Science，客座教授

2017年2月－2020年1月，西北农林科技大学食品科学与工程学院，副教授

2019年7月－2020年7月，美国Cornell University，Department of Food Science，客座副教授

2015年9月－2017年1月，西北农林科技大学食品科学与工程学院，讲师

2013年8月－2015年8月，美国University of Southern California，School of Pharmacy，联合培养博士

2010年9月－2015年6月，西北农林科技大学食品科学与工程学院，食品科学，博士

2006年9月－2010年6月，西北农林科技大学食品科学与工程学院，食品质量与安全，工学学士

二、教学内容

本科课程：《营养与代谢》、《食品营养学》、《食品营养与卫生学（甲）》、《食品营养与功能》、《食品营养综合实习》、《科技创新与论文写作》、《食品与营养科学研究方法综合实习》

研究生课程：《高级食品化学》、《现代食品营养学》、《食品科学Seminar》、《科研伦理与学术规范》（I、II）

三、主要研究方向

主要从事食品营养与人类健康研究方向，包括：

膳食模式与肠脑健康互作机制：围绕中枢神经系统和肠道功能的互作整合，针对阿尔兹海默症等神经退行性病变、压力引起的焦虑抑郁、生命早期1000天神经系统发育等脑健康问题，探究高膳食纤维饮食、间歇性禁食、氨基酸限制饮食等特色膳食模式通过影响肠道微生态结构、调节糖脂代谢平衡，进而干预中枢神经系统功能的营养干预作用，揭示膳食成分与结构通过影响外周系统进而影响脑健康的“肠-脑”轴机制；

食品营养功能组分发掘与功效评价：结合我国特色食材资源和全民营养健康现状，发掘果蔬、粮油等传统食品原料及西部特色农产品中具有调节肠道微生态、糖脂代谢稳态、改善脑健康问题等生理功能的食物功能成分，发掘有益肠脑健康的植物多酚、益生菌、益生元等。

四、科研项目

近年来主持包括中国“脑计划”重大项目，国家自然科学基金专项项目、面上项目、青年项目、陕西省重点研发计划、中国博士后特别资助、企业横向课题等科研项目20余项，主要项目包括：

1.中国“脑计划”科技创新2030重大项目，2022ZD0208100，2022-2026，主持，500万

2.国家自然科学基金面上项目，3247161928，2024-2027，主持，50万

3.国家自然科学基金专项项目，32241012，2023-2025，主持，62万

4.国家自然科学基金面上项目，81871118，2019-2023，主持，60万

5.国家自然科学基金青年项目，81803231，2019-2022，结题，20万

6.中央引导地方发展资金课题，2024-2026，主持，50万

7.汤臣倍健创新基金科学营养研究基金-创新基金，2024-2026，主持，100万深圳

五、主要著作、论文及科技奖励情况

近年来以第一或通讯作者在 Cell Metabolism 、 Nature Communications 、 iMeta 、J  Journal of Neuroinflammation 、 Redox Biology 、 Brain, Behavior, and Immunity  ,  Molecular Nutrition & Food Research 、 Journal of Agricultural and Food Chemistry 等医学、生物学、食品营养及综合领域国内外高水平杂志发表论文70余篇，总引次数达6282次，H-index 51, i10-index 84。申报国家发明专利4项，获陕西省科学技术进步奖二等奖、陕西省高等学校科学技术一等奖、2020年陕西省科技工作者创新创业大赛银奖等奖项。

学术专著

1.《营养与代谢》，主编: 刘志刚,王玉明, 2024, 中国轻工业出版社

2.《食品营养与健康科学》，主编: 刘学波, 车会莲, 参编:刘志刚, 2023, 中国林业出版社

3.Polyphenols and Flavones from Agricultural Products and Their Health-Promoting Properties, Editors: Jicheng Zhan, Zhigang Liu, and Hui-Min Wang,2024, MDPI

4.Molecular Nutrition and Mitochondria Editor: Sergej M. Ostojic, Chapter Editor:Zhigang Liu, 2022, Elsevier Academic Press

5.《糖尿病自救攻略》, 主编：William Shang, 刘志刚, 2020,Amazon KDP

代表性论文（所有论文列表请查看https://orcid.org/0000-0002-6863-6561）：

1. Yihang Zhao#, Mengzhen Jia#, Chen Ding, Bingkun Bao, Hangqi Li, Jiabin Ma, Weixuan Dong, Rui Gao, Xuhui Chen, Jiao Chen, Xiaoshuang Dai, Yuanqiang Zou, Jun Hu*, Lin Shi*, Xuebo Liu*, Zhigang Liu*. Time-restricted feeding mitigates Alzheimer's disease-associated cognitive impairments via a B. pseudolongum- propionic acid-FFAR3 axis.  iMeta , 2025, e70006.  https://doi.org/10.1002/imt2.70006

2. Yuyu Zhang, Yajie Wang, Yiju Li, Jingxi Pang, Annika Höhn, Weixuan Dong, Rui Gao, Yan Liu, Da Wang, Yongbo She, Rui Guo, Zhigang Liu*. Methionine restriction alleviates diabetes-associated cognitive impairment via activation of FGF21.  Redox Biology , 2024; 77, 103390.   https://doi.org/10.1016/j.redox.2024.103390

3. Yuyu Zhang, Tianqi Liu, Fei Pan, Yiju Li, Da Wang, Jingxi Pang, Haojie Sang, Yujia Xi, Lin Shi*, Zhigang Liu*. Dietary Methionine Restriction Alleviates Cognitive Impairment in Alzheimer's Disease Mice via Sex-Dependent Modulation on Gut Microbiota and Tryptophan Metabolism: A Multiomics Analysis. Journal of Agricultural and Food Chemistry , 2025,  73 (2), 1356–1372. https://doi.org/10.1021/acs.jafc.4c09878

4. Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu*, Zhigang Liu*. Effects of DHA on cognitive dysfunction in aging and Alzheimer's disease: The mediating roles of ApoE.  Progress in Lipid Research , 2024, 93:101256.   https://doi.org/10.1016/j.plipres.2023.101256

5. Ying He#, Bo Zhang#, Yu Xin, Wenxiu Wang, Xue Wang, Zhuo Liu, Yongbo She, Rui Guo, Gengjie Jia, Shan Wu and Zhigang Liu*. Synbiotic combination of 2’-Fucosyllactose and Bifidobacterium mitigates neurodevelopmental disorders and ASD-like behaviors induced by Valproic Acid.  Food & Function  ,  2025, 16(7):2703-2717. https://doi.org/10.1039/d4fo06234e

6. Qianxu Wang, Jiarui Liang, Qianhui Zou, Wenxiu Wang, Guiming Yan, Rui Guo, Tian Yuan, Yutang Wang*, Xuebo Liu, Zhigang Liu*. Tryptophan Metabolism-Regulating Probiotics Alleviate Hyperuricemia by Protecting the Gut Barrier Integrity and Enhancing Colonic Uric Acid Excretion.    Journal of Agricultural and Food Chemistry , 2024; 72, 48, 26746-26761. https://doi.org/10.1021/acs.jafc.4c07716

7. Yuxuan Deng #, Qingyuan Li #, Junxian Song, Rui Guo, Tianchen Ma, Zhigang Liu*, Qian Liu*. Intervention effects of low-molecular-weight chondroitin sulfate from the nasal cartilage of yellow cattle on lipopolysaccharide-induced behavioral disorders: regulation of the microbiome-gut-brain axis.  Frontiers in Nutrition , 2024,11:1371691. https://doi.org/10.3389/fnut.2024.1371691

8. Jian-Rong Zheng, Jun-Lei Chang, Jun Hu, Zhi-Jian Lin, Kai-Hua Lin, Bi-Hua Lu, Xu-Hui Chen*, Zhi-Gang Liu*. Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report.  World Journal of Radiology,  2024, 16(9):446-452. https://dx.doi.org/10.4329/wjr.v16.i9.446

9. Hongbo Zhang, Chaoyue Li, Lin Han, Yao Xiao, Ji Bian, Chao Liu, Lan Gong, Zhigang Liu*, Min Wang*. MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis.  Gut Microbes , 2024; 16(1), 2367342. https://doi.org/10.1080/19490976.2024.2367342

10. Mengzhen Jia^#; Fangjie Ning^#; Junqing Wen; Xiaorui Wang; Jiao Chen; Jun Hu; Xuhui Chen*; Zhigang Liu*. Secoisolariciresinol diglucoside attenuates neuroinflammation and cognitive impairment in female Alzheimer's disease mice via modulating gut microbiota metabolism and GPER/CREB/BDNF pathway.    Journal of Neuroinflammation , 2024; 21(1):201. https://doi.org/10.1186/s12974-024-03195-4

11. Ling Li^#; Cong Yang^#; Mengzhen Jia; Yuhao Wang; Yu Zhao; Qingyuan Li; Jun Gong; Ying He; Kun Xu; Xuebo Liu; Xuhui Chen*; Jun Hu*; Zhigang Liu*. Synbiotic of Clostridium sporogenes and xylan promotes gut-derived indole-3-propionic acid and improves cognitive impairments in Alzheimer's disease mouse model.  Food & Function , 2024; 15(4):2249–2264. https://doi.org/10.1039/d4fo00886c

12. Qianhui Zou; Shiyao Han; Jiarui Liang; Qianxu Wang; Yajie Wang; Zilong Zhang; Jun Hu; Jufang Li; Tian Yuan; Zhigang Liu*. Alleviating Effect of Vagus Nerve Cutting in Salmonella-Induced Gut Infections and Anxiety-Like Behavior via Microbiota-Derived GABA.  Brain Behavior and Immunity ,   2024; 119:607–20. https://doi.org/10.1016/j.bbi.2024.04.034.

13. Rui Guo^#; Xiao Xiao^#; Chuanchuan Wang; Tian Yuan; Qianhui Zou; Tian Zhang; Jiarui Liang; Ying He; Zhuo Liu; Xuebo Liu; Shan Wu*; Zhigang Liu*. Bovine and Goat Milk Fat Globule Membrane Supplementation Alleviates Autism-like Behavior by Modulating Lipid Metabolism and Gut Microbiota.  Food Science and Human Wellness , (2024, Accepted).https://doi.org/10.26599/FSHW.2024.9250159.

14. Xin Zhang^#; Tianzhi Xie^#; Shuang Zhou^#; Yingxuan Yuan; Weixuan Chen; Jie Zheng; Xuebo Liu; Tian Yuan*; Yanhui Lu*; Zhigang Liu*. Effects of ApoE Genotype on Cognitive Function in Aging Mice Fed with High-Fat Diet and the Protective Potential of n-3 Polyunsaturated Fatty Acids.  Food & Function , 2024; 15(4): 2249–2264. https://doi.org/10.1039/d3fo03965j.

15. Chuanchuan Wang; Weixuan Chen; Yishan Jiang; Xiao Xiao; Qianhui Zou; Jiarui Liang; Yu Zhao; Qianxu Wang; Tian Yuan; Rui Guo; Xuebo Liu*; Zhigang Liu*. A synbiotic formulation of Lactobacillus reuteri and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut–brain axis.  Food & Function , 2024; 15(1):387–400. https://doi.org/10.1039/d3fo02663a

16. Yujia Xi^#; Yuyu Zhang^#; Yiwen Zhou; Qing Liu; Xuhui Chen; Xuebo Liu; Tilman Grune; Lin Shi*; Min Hou*; Zhigang Liu*. Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP/PS1 Alzheimer's Disease model mice: Role of the cystathionine-β-synthase/H2S pathway.  Redox Biology , 2023; 59:102595. https://doi.org/10.1016/j.redox.2022.102595

17. Yajie Wang; Yuyu Zhang; Xinyu Wang; Qingyuan Li; Yu Zhao; Yishan Jiang; Rui Guo; Xuebo Liu; Tian Yuan*; Zhigang Liu*. Sesamol mitigates chronic iron overload-induced cognitive impairment and systemic inflammation via IL-6 and DMT1 regulation.  Molecular Nutrition & Food Research , 2023; 67:2300012. https://doi.org/10.1002/mnfr.202300012

18. Rui Guo^#; Jingxi Pang^#; Junhe Zhao; Xiao Xiao; Jing Li; Jingmeng Li; Wenxiu Wang; Shuang Zhou; Yu Zhao; Zilong Zhang; Hongwang Chen; Tian Yuan; Shan Wu*; Zhigang Liu*. Unveiling the neuroprotective potential of dietary polysaccharides: a systematic review.  Frontiers in Nutrition , 2023; 10:1299117. https://doi.org/10.3389/fnut.2023.1299117. (Review)

19. Zhigang Liu*; Qian Liu; Guoyuan Qi. Editorial: Dietary polysaccharides and brain health. Editorial: Dietary polysaccharides and brain health.  Frontiers in Nutrition , 2023, 10: 1249498. https://doi.org/10.3389/fnut.2023.1249498

20. Tiantian Zhang*; Zhigang Liu; Yashi Mi. Editorial: Nutritional interventions on age-related neurodegenerative diseases.  Frontiers in Aging Neuroscience , 2023; 15:1215586. https://doi.org/10.3389/fnagi.2023.1215586

21. Jiachen Ma; Tian Yuan; Yuqi Gao; Xiaoming Zeng; Zhigang Liu*; Jinming Gao*. Torreya grandis oil attenuates cognitive impairment in scopolamine-induced mice.  Food & Function , 2023; 14(23): 10520–10534. https://doi.org/10.1039/d3fo03800a.

22. Yuyu Zhang^#; Julia Jelleschitz^#; Tilman Grune; Weixuan Chen; Yihang Zhao; Mengzhen Jia; Yajie Wang; Zhigang Liu*; Annika Höhn*. Methionine restriction - Association with redox homeostasis and implications on aging and diseases.  Redox Biology , 2022; 57:102464. https://doi.org/10.1016/j.redox.2022.102464

23. Jiang Jiang Tang^#; Lan Fang Huang^#; Jia Le Deng; Yi Meng Wang; Cong Guo; Xiao Na Peng; Zhigang Liu*; Jinming Gao*. Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model.  Redox Biology , 2022; 50:102229. https://doi.org/10.1016/j.redox.2022.102229

24. Ying Lan; Qingyang Sun; Zhiyuan Ma; Jing Peng; Mengqi Zhang; Chi Wang; Xiaotian Zhang; Xianfang Yan; Lili Chang; Xinglin Hou; Ruixue Qiao; Aiziguli Mulati; Yuan Zhou; Qiang Zhang; Zhigang Liu*; Xuebo Liu*. Seabuckthorn polysaccharide ameliorates high-fat diet-induced obesity by gut microbiota-SCFAs-liver axis.  Food & Function , 2022; 13(5):2925-2937. https://doi.org/10.1039/D1FO03147C

25. Lei Wang; Weixuan Chen; Yujie Tian; Xiaorong Duan; Yi Yuan; Na Wang; Chao Xu; Xuebo Liu*; Zhigang Liu*. Preventive Effects of Sesamol on Deep‐Frying Oil‐Induced Liver Metabolism Disorders by Altering Gut Microbiota and Protecting Gut Barrier Integrity.  Molecular Nutrition & Food Research , 2022; 66(9):e2101122. https://doi.org/10.1002/mnfr.202101122

26. Yihang Zhao; Mengzhen Jia; Weixuan Chen; Zhigang Liu*. The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function.  Free Radical Biology & Medicine , 2022; 182:206-218. https://doi.org/10.1016/j.freeradbiomed.2022.02.021

27. Wentong Zhang; Jun Wang; Luanfeng Wang; Renjie Shi; Chuanqi Chu; Zhiling Shi ; Pujie Liu; Yitong Li; Xuebo Liu; Zhigang Liu*. Alternate-day fasting prevents non-alcoholic fatty liver disease and working memory impairment in diet-induced obese mice.  The Journal of Nutritional Biochemistry , 2022; 110:109146. https://doi.org/10.1016/j.jnutbio.2022.109146

28. Qing Liu^#; Tianzhi Xie^#; Yujia Xi^#; Ling Li; Fengfeng Mo; Xuebo Liu; Jin-Ming Gao; Zhigang Liu*; Tian Yuan*. Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut-Brain Axis.  Journal of Agricultural and Food Chemistry , 2021; 69(43):12717–12729. https://pubs.acs.org/doi/10.1021/acs.jafc.1c04687

29. Bo Ren^#; Luanfeng Wang^#; Lin Shi; Xin Jin; Yan Liu; Rui Hai Liu; Fei Yin; Enrique Cadenas; Xiaoshuang Dai; Zhigang Liu*, Xuebo Liu*. Methionine restriction alleviates age-associated cognitive decline via fibroblast growth factor 21.  Redox Biology , 2021; 41:101940. https://doi.org/10.1016/j.redox.2021.101940

30. Qing Liu^#; Yujia Xi^#; Qianxu Wang; Jinhui Liu; Peiran Li; Xue Meng; Kai Liu; Weixuan Chen; Xuebo Liu; Zhigang Liu*. Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis.  Brain, Behavior, and Immunity , 2021; 95:330-343. https://doi.org/10.1016/j.bbi.2021.04.005

31. Xiaoning Liu^#; Xiang Li^#; Bing Xia; Xin Jin; Qianhui Zou; Zhenhua Zeng; Weiyang Zhao; Shikai Yan; Ling Li; Shufen Yuan; Shancen Zhao; Xiaoshuang Dai; Fei Yin; Enrique Cadenas; Rui Hai Liu; Beita Zhao; Min Hou*; Zhigang Liu*; Xuebo Liu*. High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis.  Cell Metabolism  2021; 33(5):923-938.e6. https://doi.org/10.1016/j.cmet.2021.02.002

32. Zhigang Liu*^#; Xiaoshuang Dai^#; Hongbo Zhang; Renjie Shi; Yan Hui; Xin Jin; Wentong Zhang;Luanfeng Wang;Qianxu Wang; Danna Wang; Jia Wang; Xintong Tan; Bo Ren; Xiaoning Liu; Tong Zhao; Jiamin Wang; Junru Pan; Tian Yuan; Chuanqi Chu; Lei Lan; Fei Yin; Enrique Cadenas; Lin Shi*; Shancen Zhao*; Xuebo Liu*. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.  Nature Communications , 2020; 11(1):855. https://doi.org/10.1038/s41467-020-14676-4

33. Xin Zhang; Qianhui Zou; Beita Zhao; Jingwen Zhang; Weiyang Zhao; Yitong Li; Ruihai Liu; Xuebo Liu; Zhigang Liu*. Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.  Redox Biology , 2020; 32:101535. https://doi.org/10.1016/j.redox.2020.101535

34. Zhigang Liu^#; Ling Li^#; Shaobo Ma; Jin Ye; Hongbo Zhang; Yitong Li; Ali Tahir Sair; Junru Pan; Xiaoning Liu; Xiang Li; Shikai Yan; Xuebo Liu*. High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved.  Journal of Agricultural and Food Chemistry , 2020; 68, 47:13697–13710. https://pubs.acs.org/doi/10.1021/acs.jafc.0c04290

35. Hongbo Zhang; Wentong Zhang; Duo Yun; Ling Li; Weiyang Zhao; Yitong Li; Xuebo Liu*; Zhigang Liu*. Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: Roles of FGF21 and bile acids.  Journal of Nutritional Biochemistry  2020; 83:108403. https://doi.org/10.1016/j.jnutbio.2020.108403

36. Qianhui Zou; Xin Zhang; Xiaoshuang Liu; Yitong Li; Qiaoli Tan; Qin Dan; Tian Yuan; Xuebo Liu; Ruihai Liu; Zhigang Liu*. Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice.  Food & function  2020; 11(7):6666-6679. https://doi.org/10.1039/D0FO01162B

37. Luanfeng Wang^#; Bo Ren^#; Qian Zhang; Chuanqi Chu; Zhenting Zhao; Jianbin Wu; Weiyang Zhao; Zhigang Liu*, Xuebo Liu*. Methionine Restriction Alleviates High-Fat Diet-induced Obesity: Involvement of Diurnal Metabolism of Lipids and Bile Acids.  Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease    2020; 1866(11):165908. https://doi.org/10.1016/j.bbadis.2020.165908

38. Luanfeng Wang; Bo Ren; Yan Hui; Chuanqi Chu; Zhenting Zhao; Yuyu Zhang; Beita Zhao; Renjie Shi; Junli Ren; Xiaoshuang Dai*; Zhigang Liu*; Xuebo Liu*. Methionine Restriction Regulates Cognitive Function in High-fat Diet-fed Mice: Roles of Diurnal Rhythms of SCFAs Producing‐and Inflammation‐related Microbes.  Molecular Nutrition & Food Research , 2020; 64(17):2000190. https://doi.org/10.1002/mnfr.202000190

39. Jia Wang; Tonghui Geng; Qianhui Zou; Ningru Yang; Weiyang Zhao; Yitong Li; Xintong Tan; Tian Yuan; Xuebo Liu, Zhigang Liu*. Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function.  Journal of Functional Foods , 2020; 67:103857. https://doi.org/10.1016/j.jff.2020.103857

40. Bo Ren; Tian Yuan; Xinglin Zhang; Luanfeng Wang; Junru Pan; Yan Liu; Beita Zhao; Weiyang Zhao; Zhigang Liu*; Xuebo Liu*. Protective Effects of Sesamol on Systemic Inflammation and Cognitive Impairment in Aging Mice.  Journal of Agricultural and Food Chemistry , 2020; 68(10):3099-3111. https://pubs.acs.org/doi/10.1021/acs.jafc.9b07598

41. Aiziguli Mulati; Shaobo Ma; Hongbo Zhang; Bo Ren; Beita Zhao; Luanfeng Wang; Xiaoning Liu; Tong Zhao; Svetlana Kamanova; Ali Tahir Sair; Zhigang Liu*; Xuebo Liu*. Sea-Buckthorn Flavonoids Alleviate High-Fat and High-Fructose Diet-Induced Cognitive Impairment by Inhibiting Insulin Resistance and Neuroinflammation.  Journal of Agricultural and Food Chemistry , 2020; 68(21):5835-5846. https://pubs.acs.org/doi/10.1021/acs.jafc.0c00876

42. Shikai Yan; Renjie Shi; Ling Li; Shaobo Ma; Hongbo Zhang; Jin Ye; Jiamin Wang; Junru Pan; Qianxu Wang; Xiang Jin; Xuebo Liu; Zhigang Liu*. Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western-Diet-Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short-Chain Fatty Acids Production.  Molecular Nutrition & Food Research , 2019; 63(23):e1900521. https://doi.org/10.1002/mnfr.201900521

43. Xintong Tan; Ling Li; Jia Wang; Beita Zhao; Junru Pan; Leran Wang; Xiao Liu; Xuebo Liu; Zhigang Liu*. Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes.  Journal of Agricultural and Food Chemistry , 2019; 67(31):8510-8519. https://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b03368

44. Cover Article: Qianxu Wang; Mengzhen Jia; Yihang Zhao; Yan Hui; Junru Pan; Hongfei Yu; Shikai Yan; Xiaoshuang Dai; Xuebo Liu; Zhigang Liu*. Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure.  Journal of Agricultural and Food Chemistry , 2019; 67(45):12441-12451. https://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b03652

45. Yihang Zhao; Qianxu Wang; Mengzhen Jia; Shangchen Fu; Junru Pan; Chuanqi Chu; Xiaoning Liu; Xuebo Liu; Zhigang Liu*. (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation.  Journal of Nutritional Biochemistry , 2019; 64:61-71. https://doi.org/10.1016/j.jnutbio.2018.10.006

46. Tian Yuan; Chuanqi Chu; Rubing Shi; Tianlin Cui; Xinglin Zhang; Yihang Zhao; Xu Shi; Yan Hui; Junru Pan; Rui Qian; Xiaoshuang Dai; Zhigang Liu*; Liu, Xuebo*. ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut-Brain Axis.  Journal of Agricultural and Food Chemistry , 2019; 67(22):6190-6201. https://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b01436

47. Guoyuan Qi; Yashi Mi; Rong Fan; Zhigang Liu*; Xuebo Liu*. Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways.  Journal of Agricultural and Food Chemistry , 2019; 67(18):5122-5134. https://doi.org/10.1021/acs.jafc.9b00133

48. Zhigang Liu^#; Xiaoning Liu^#; Shunyi Luo; Chuanqi Chu; Dandan Wu; Runhua Liu; Lei Wang; Jiamin Wang; Xuebo Liu*. Extract of sesame cake and sesamol alleviate chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits.  Journal of Functional Foods , 2018; 42:237-247. https://doi.org/10.1016/j.jff.2018.01.005

49. Beita Zhao; Hua Liu; Jiamin Wang; Pujie Liu; Xintong Tan; Bo Ren; Zhigang Liu*; Xuebo Liu*. Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice.  Journal of Agricultural and Food Chemistry , 2018; 66(12):3127-3136. https://doi.org/10.1021/acs.jafc.7b05770

50. Rui Guo; Beita Zhao; Yijie Wang; Dandan Wu; Yutang Wang; Yafan Yu; Yuchen Yan; Wentong Zhang; Zhigang Liu*; Xuebo Liu*. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells.  Journal of Agricultural and Food Chemistry , 2018; 66(37):9667-9678. https://pubs.acs.org/doi/abs/10.1021/acs.jafc.8b02147

51. Jia Wang; Zhuo Wang; Bing Li; Yu Qiang; Tian Yuan; Xintong Tan; Zihan Wang; Zhigang Liu*; Xuebo Liu*. Lycopene attenuates western-diet induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis.  International Journal of Obesity , 2018; 43(9):1735-1746. https://doi.org/10.1038/s41366-018-0277-9

52. Jia Wang; Lixia Li; Zhuo Wang; Yifan Cui; Xintong Tan; Tian Yuan; Qian Liu; Zhigang Liu*; Xuebo Liu*. Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress.  Journal of Nutritional Biochemistry , 2018; 56:16-25. https://doi.org/10.1016/j.jnutbio.2018.01.009

53. Zhigang Liu^#; Yuwei Chen^#; Qinglian Qiao; Yali Sun; Qian Liu; Bo Ren; Xuebo Liu*. Sesamol supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB.  Molecular Nutrition & Food Research , 2017; 61(5):10. https://doi.org/10.1002/mnfr.201600734

54. Zhigang Liu^#; Yali Sun^#; Qinglian Qiao; Tong Zhao; Wentong Zhang; Bo Ren; Qian Liu; Xuebo Liu*. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system.  Food & function , 2017; 8(2):710-719. https://doi.org/10.1039/C6FO01562J

55. Zhigang Liu; Patil Ishan; Sancheti Harsh; Yin Fei; Cadenas Enrique*. Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and ¹³C-NMR Study.  Scientific Reports  2017; 7(1):5391. https://doi.org/10.1038/s41598-017-05217-z

56. Qian Liu; Yaya Hu; Youfang Cao; Ge Song; Zhigang Liu*; Xuebo Liu*. Chicoric acid ameliorates lipopolysaccharide-induced oxidative stress via promoting the Keap1/Nrf2 transcriptional signaling pathway in BV-2 microglial cells and mouse brain.  Journal of Agricultural and Food Chemistry , 2017; 65(2):338-347. https://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b04873

57. Zhigang Liu; Bo Ren; Yihui Wang; Chen Zou; QinglianQiao; Zhijun Diao; Yashi Mi; Di Zhu; Xuebo Liu*. Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy.  Scientific Reports , 2017; 7:45728. https://doi.org/10.1038/srep45728

58. Ge Song^#; Zhigang Liu^#; Luanfeng Wang; Renjie Shi; Chuanqi Chu; Man Xiang; Qi Tian; Xuebo Liu*. Protective effects of lipoic acid against acrylamide-induced neurotoxicity: involvement of mitochondrial energy metabolism and autophagy.  Food & function , 2017; 8:4657-4667. https://doi.org/10.1039/C7FO01429E

59. Guoyuan Qi^#; Zhigang Liu^#; Rong Fan; Ziru Yin; Yashi Mi; Bo Ren; Xuebo Liu*. Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells.  Scientific Reports , 2017; 7(1):2275. https://doi.org/10.1038/s41598-017-02573-8

60. Qian Liu; Yuwei Chen; Chun Shen; Yating Xiao; Yutang Wang; Zhigang Liu*; Xuebo Liu*. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB.  FASEB Journal , 2017; 31(4):1494-1507. https://doi.org/10.1096/fj.201601071R

61. Zhigang Liu; Ge Song; Chen Zou; Gongguan Liu; Wanqiang Wu; Tian Yuan; Xuebo Liu*. Acrylamide induces mitochondrial dysfunction and apoptosis in BV-2 microglial cells.  Free Radical Biology & Medicine , 2015; 84:42-53. https://doi.org/10.1016/j.freeradbiomed.2015.03.013

62. Zhigang Liu; Ishan Y Patil; Tianyi Jiang; Harsh Sancheti; John P Walsh; Bangyan L Stiles; Fei Yin; Enrique Cadenas*. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity.  PLoS One , 2015; 10(5):e0128274. https://doi.org/10.1371/journal.pone.0128274

63. Zhigang Liu; Qisen Xiang; Lihui Du; Ge Song; Yutang Wang; Xuebo Liu*. The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells.  Food Chemistry , 2013; 141(1):289-296. https://doi.org/10.1016/j.foodchem.2013.02.105

64. 梁家瑞; 温明赫; 陈玮萱; 蒲小平; 闾中平; 原田; 刘志刚. 益生菌及后生元对胃部幽门螺杆菌感染的改善作用《现代食品科技》, （2024, 已接收）.

65. 张滋龙; 杨雅娴; 李竞萌; 李菁; 王玉堂; 原田; 郭瑞; 刘志刚. 萌发芝麻提取物对鼠伤寒沙门氏菌感染小鼠焦虑和肠道炎症的改善作用《粮油食品科技》, （2024, 已接收）.

66. 丁辰; 何颖; 刘琳文; 郭瑞; 原田; 刘志刚. 花果超微粉研制及改善便秘功效研究《中国食品学报》, （2024, 已接收）.

67. 刘志刚; 贾梦真. 膳食营养干预与脑健康:调整饮食节律中的“肠-脑”轴机制研究进展《中国食品学报》, 2023, 23(2):1-13.

68. 王千诩; 蒲小平; 闾中平; 原田; 刘志刚#; 郭瑞#. 后生元对机体健康影响的研究进展及其应用前景《中国食品添加剂》, 2023, 34(1):62-74.

69. 郭瑞; 周爽; 王文秀; 宁方杰; 李青原; 刘志刚. β-葡聚糖的营养健康功能研究进展《粮油食品科技》, 2023, 31(1):33-39.

70.  刘学波; 刘小宁; 原田; 刘志刚*. 芝麻酚的神经保护作用及分子机制《中国食品学报》, 2017;17(10):1-7.

71. 刘学波*; 张文彤; 郭瑞; 刘志刚. 高脂高果糖膳食影响脑认知功能的分子机制与研究进展《中国食品学报》, 2016;16(10):1-9. EI

72. 刘学波; 刘志刚. 线粒体介导食品功能因子活性与食品危害物毒性的分子机制《中国食品学报》, 2015;15(10):1-8. EI

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